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In tissues outside the brain, fasting robustly decreased cytoplasmic acetyl-CoA levels (Mario et al., 2014) due to reduced insulin signaling decreasing ACLY expression (Liang et al., 2002

Vailati Negrao, M, Paula, AG, Molkentine, D, Hover, LD, Nilsson, M, Vokes, N, Engstrom, LD, Calinisan, A, Briere, DM, Waters, L, Hallin, J, Diao, L, Altan, M, Blumenschein, GR, Skoulidis, F, Wang, J, Kopetz, S , Hong, DS, Gibbons, DL, Olson, P, Christensen, JG, Heymach, JV

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Below is a synthesis of the latest data through 2025

2011;11 Suppl 3:S19